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in Medical Academics Questions by Doctor of Medicine (9.9k points)
If One baby has down syndrome, what is the risk of the other baby having down syndrome?

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by Medical Officer (1.8k points)
**First of all we need to know the cause of down syndrome-**
1. Non-dysjunction that occurs in 95% cases
2. Translocation- 4%
3. Mosaicism- 1%

For a non-dysjunction recurrence risk is same as the population for that maternal age.

For Translocations- t(21:21) in parents is associated with 100% recurrence of down syndromein subsequent pregnancy.
    t(4:11) is associated with 5-7% recurrence rate

If a mother has Down Syndrome, she can still be fertile and able to reproduce, with chance of having a baby with downsyndrome by 50%

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