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Cause of isolated increase in aPTT

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We have a patient with isolated increase in aPTT > 3 times normal range. His PT is normal. Factor assay is normal for factor 8,9 . What are the causes?

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1 Answer

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Lupus anti-coagulant (anti-phospholipid syndrome)
Heparin exposure
Haemophilia A and B (Factor VIII and IX deficiency respectively)
Factor XII deficiency
Factor XI deficiency
Contact factor deficiency e.g. pre-kallikrein (not clinically important)
Artefactual - Lab error

It all I found
Any more?

answered Mar 17, 2014 by Sujit Shrestha Medical Officer (1,796 points)
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