CO2 + H2O <--(CA)--> H2CO3 <--> H+ + HCO3- (Bohr: left to right; Haldene: right to left)
Bohr effect:
Affinity of hemoglobin to O2 decreases when pH of blood falls
Facilitates release of O2 in tissues: Increased CO2 in blood --> Increased H+ production --> H+ binds to deoxyhemoglobin --> accesibility of O2 to Hemoglobin decreases --> O2 released
Haldene effect:
Binding of 02 with Hemoglobin tends to displace CO2 from blood (opposite of Bohr's effect)
Facilitates release of CO2 in lungs: HHb + O2 --> HbO2 + H+; H+ + HCO3- --> CO2 + H20
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