0
What is delta bilirubin?

Your answer

Preview

Your name to display (optional):
Privacy: Your email address will only be used for sending these notifications.
Anti-spam verification:
Please answer to the question.
To avoid this verification in future, please log in or register.

2 Answers

0

Glucoronides are chemically reactive metabolites. In adults, with prolonged cholestasis especially if it is accompanied by renal failure, a fraction of the bilirubin conjugates readily non enzymatically and irreversibly with serum albumin to give yellow billiproteins in which bilirubin is covalently bound to albumin. This fraction increases with the duration of cholestasis and is designated as delta bilirubin.

Delta bilirubin retains its direct reading properties. As delta bilirubin is irreversibly bound to albumin it is not filtered at the glomerulus and its half life reflects that of albumin (14 days). Consequently it remains in plasma long after other bilirubin esters have been eliminated giving rise to conjugated hyperbilirubinemia in the absence of bilirubinuria and is particularly evident in the recovery phase of cholestasis.

Delta bilirubin = Total bilirubin- (Conjugated + Unconjugated bilirubin)

answered Sep 17, 2015 by admin Doctor of Medicine (9,909 points)
0

It is the component of bilirubin synthesised due to the ineffective erythropoesis (rbcs 'that are destroyed in the bone marrow itself ).it gets conjugated and binds covalently to serum albumin

answered Apr 4 by anonymous
...