Uric acid concentration is often elevated before development of clinical signs and symptoms in pre-eclampsia. Following are the hypothesis on the reason of hyperuricemia in gestational hypertension:
- Reduced renal clearance
- Hypovolemia (increases uric acid reabsorption)
- Increased uric acid production from maternal, fetal or placental tissues through heightened tissues breakdown (ie. increased substrate availability)
- Increased Xanthine Oxidase (XO) activity
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