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What is the difference between Pregabalin and Gabapentin?

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asked Nov 17, 2015 in Medical Academics Questions by Sulabh Shrestha Doctor of Medicine (5,553 points)

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Pregabalin and Gabapentin both are GABA analogues.

  • The potency of Pregabalin is higher than that of Gabapentin. It produces effect at lesser dosage and hence the resultant adverse effects are lesser common.
  • The kinetics of Pregabalin is 1st order while that of Gabapentin is zero order. The pharmacokinetics of Pregabalin is more predictable than that of Gabapentin.
answered Nov 18, 2015 by admin Doctor of Medicine (9,909 points)
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