What is the difference between Pregabalin and Gabapentin?

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Pregabalin and Gabapentin both are GABA analogues.

  • The potency of Pregabalin is higher than that of Gabapentin. It produces effect at lesser dosage and hence the resultant adverse effects are lesser common.
  • The kinetics of Pregabalin is 1st order while that of Gabapentin is zero order. The pharmacokinetics of Pregabalin is more predictable than that of Gabapentin.
answered Nov 18, 2015 by admin Doctor of Medicine (10,059 points)