Does Hypernatremia cause elevated CSF protein ?

Question

I have seen lot of cases where csf protein is raised in hypernatrmic patients.
Is this a phenomena or just a finding in my cases.

Is there a mechanism?

Answer 1

CSF and plasma are in the state of equilibrium - increase in plasma sodium can lead to pulling out of water from the csf - thus a relative state of hypoproteinemia. This might be areason but just a guess.

Answer 2

The cerebrospinal fluid (CSF) protein is often elevated in infants with significant hypernatremia, probably owing to leakage from damaged blood vessels. Neonates, especially if premature, seem especially vulnerable to hypernatremia and excessive sodium intake

Quoted from Nelson Text book