What is Monro-Kellie hypothesis?

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The sum of the volume of the brain, blood, and CSF within the skull must remain constant. Therefore, an increase in one of the above must be offset by an decreased volume of the others. If not, the ICP will increase.

Increased ICP can thus result in cerebral herniation, or when ICP = systolic blood pressure (BP), cerebral blood flow ceases and brain death occurs.

answered Jun 1, 2013 by Sulabh Shrestha Doctor of Medicine (5,553 points)