Why pigmentation occurs in Primary adrenocortical insufficiency but not in secondary adrenocortical insufficiency?

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In primary adrenocortical insufficiency i.e. Addison's disease, there is hypersecretion of ACTH through feedback regulation
Secondary adrenocortical insufficiency itself is caused by deficiency of ACTH
ACTH and MSH are synthesized from Pro-opiomelanocortin (POMC)

answered Jul 10, 2012 by Sulabh Shrestha Doctor of Medicine (5,553 points)