Why there is hypercholesterolemia in myxedema?

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Insulin and thyroid hormones positively affect hepatic LDL-receptor interactions; therefore, the hypercholesterolaemia and increased risk of atherosclerosis associated with uncontrolled diabetes or hypothyroidism is likely due to decreased hepatic LDL uptake and metabolism. The precise mechanism for these effects is unclear, but it may be mediated through the regulation of apo-B degradation.

answered Oct 5, 2012 by Sulabh Shrestha Doctor of Medicine (5,553 points)