Why thiazide is used to treat calcium stones?

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Thiazide inhibits luminal Na+ and Cl- contransporter in distal tubule. This leads to increased calcium reabsorption through transpotential voltage gated channel. It also stimulate Ca++ - H+ channel on interstitial side leading to increased calcium absorption. Hence, this is used in cases of hypercalciuria which leads to formation of calcium oxalate stones in urinary system.

answered Nov 25, 2015 by admin Doctor of Medicine (10,059 points)