Why hypokalemia precipitates digoxin toxicity?

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1 Answer


Remember the mechanism of action of digoxin. It binds to and inhibits the Na+-K+ ATPase pump. Digoxin and K+ binds at the same site on Na+K+ ATPase pump. Thus, a decrease in serum K+ means and increased digoxin binding to this pump leading to toxicity.

answered Sep 6, 2016 by admin Doctor of Medicine (10,059 points)