Why oxygen therapy must be given with caution in COPD?

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I know it stops respiration but how?

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Chronic lung diseases cuase chronic general asphyxia (Increased PCO2 and Decreased PO2) due to decreased alveolar ventilation. And it is characterized by:

  • respiration is stimulated by both decreased PO2 and increased PCO2
  • persistent hypercapnia leads to decreased response of breathing center to CO2 due to increased HCO3- transfer from blood to CSF
  • hypoxia is the means for respiratory drive

Hence, if the hypoxic drive is lost due to excessive O2 therapy, respiration stops.

answered Jun 12, 2012 by Sulabh Shrestha Doctor of Medicine (5,553 points)
commented Sep 6, 2012 by anonymous
good explanation

From Our Facebook page "Medical Online Magazine" :

Asmira Basic: Because it may worsen hypercapnia in some situations.

Samir Ratna Bajracharya: excess of O2 might cause depression of the respiratory center in the brain causing respiratory failure.

Shanti Gurung: because low arterial oxygen level is the client's primary drive for breathing.

answered Jun 14, 2012 by admin Doctor of Medicine (10,059 points)