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Why is the risk of cardiovascular diseases increased in megaloblastic anemia?
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asked
Jul 17, 2012
in
Medical Academics Questions
by
anonymous
pathology
medicine
cardiovascular
anemia
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Jul 21, 2012
by
Sulabh Shrestha
Doctor of Medicine
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![Hyperhomocysteinemia in Megaloblastic anemia][1]
There is a block in conversion of homocysteine to methionine resulting in hyperhomocysteinemia. Premature atherosclerosis and thromboembolism occurs - due to ↑ plasma homocysteine (increased plasma homocysteine found in 40% of all atherosclerosis patients). Hence, there is an increased risk of cardiovascular diseases in megaloblastic anemia.
The mechanism of atherosclerosis associated with homocystinuria is shown below:
![atherosclerosis in homocystinuria][2]
[1]:
http://ars.els-cdn.com/content/image/1-s2.0-S0920121100001017-gr1.gif
[2]:
https://lh3.googleusercontent.com/-cM1A6M0pbi4/UArKEVrDSZI/AAAAAAAABPE/Ll4-30yGQSM/s600/homocysteine%2520atherosclerosis.gif
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