2
Why is the risk of cardiovascular diseases increased in megaloblastic anemia?

Open 1 Answers 16529 Views Medical Academics Questions
asked Jul 17, 2012 in Medical Academics Questions by anonymous

Tags

Your answer

Preview
Your name to display (optional):
Privacy: Your email address will only be used for sending these notifications.
Anti-spam verification:
Please answer to the question.
To avoid this verification in future, please log in or register.

1 Answer

0

Hyperhomocysteinemia in Megaloblastic anemia

There is a block in conversion of homocysteine to methionine resulting in hyperhomocysteinemia. Premature atherosclerosis and thromboembolism occurs - due to ↑ plasma homocysteine (increased plasma homocysteine found in 40% of all atherosclerosis patients). Hence, there is an increased risk of cardiovascular diseases in megaloblastic anemia.

The mechanism of atherosclerosis associated with homocystinuria is shown below:

atherosclerosis in homocystinuria

answered Jul 21, 2012 by Sulabh Shrestha Doctor of Medicine (5,553 points)
...