Why is the risk of cardiovascular diseases increased in megaloblastic anemia?

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Hyperhomocysteinemia in Megaloblastic anemia

There is a block in conversion of homocysteine to methionine resulting in hyperhomocysteinemia. Premature atherosclerosis and thromboembolism occurs - due to ↑ plasma homocysteine (increased plasma homocysteine found in 40% of all atherosclerosis patients). Hence, there is an increased risk of cardiovascular diseases in megaloblastic anemia.

The mechanism of atherosclerosis associated with homocystinuria is shown below:

atherosclerosis in homocystinuria

answered Jul 21, 2012 by Sulabh Shrestha Doctor of Medicine (5,553 points)