Is it possible to have anaphylaxis to adrenaline itself ?

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How can we manage an anaphylactic shock in such case?

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No. Adrenaline/Epinephrine is produced naturally in humans by adrenal glands against "flight and fright" reaction. Any stress reaction reaction would thus initiate an uncontrolled positive feedback loop if we were to be anaphylactic to adrenaline. Situations of flight and fright would lead to release of adrenaline which would lead to collapse. This in turn would trigger release of more adrenaline.

answered Oct 9, 2015 by admin Doctor of Medicine (10,059 points)